EUROSERPIN2025 Programme (provisional)

 

Monastero di San Faustino Maggiore, Brescia, 28-30 May 2025

 

 

Wednesday 28th May 2025

 

13:00-14:00        Registration

 

14:00-14:15        Welcome address

 

Session 1 - Serpins in health and disease I - 14:15-17:40

 

Robin Carrell (University of Cambridge, UK)

 

Stefan Marciniak (University of Cambridge, UK)
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency

 

Rick Sifers (Baylor College of Medicine, USA)
Utilization of SERPINA1 and patient genetics to elucidate the regulation of the Hepatocyte Proliferation Response

 

John Heiker (Helmholtz Munich, Germany)
DNA binding of vaspin (SERPINA12)

 

Sonia Caccia (University of Milan, Italy)
Impact of C1-inhibitor binding to endothelial cells on the regulation of vascular permeability

 

Coffee break

 

Sabina Janciauskiene (Hannover Medical School, Germany)
α-1-Antitrypsin C-terminal peptides: biomarkers and therapeutic targets in disease

 

Javier Corral (University of Murcia-IMIB, Spain)
Antithrombin deficiency update. What's up doc?

 

Speakers to be selected from abstracts

 

 

Thursday 29th May 2025

 

Session 2 – Therapies, diagnostics and disease models - 9:00-13:00

 

David Lomas (University College London, UK)
Towards a small molecule therapy for alpha-1 antitrypsin deficiency

 

Patrizia Pontisso (University of Padova, Italy)

 

Speakers to be selected from abstracts

 

Coffee break

 

Alexandra Lucas (Arizona State University, USA)

 

Tamir Rashid (Imperial College London, UK)
Induced pluripotent stem cell therapies

 

Beatriz Martinez Delgado (Carlos III Health Institute, Spain)
Metabolic alterations in AATD cellular models and patient-derived liver organoids

 

Speakers to be selected from abstracts

 

13:00-14:00        Lunch (provided)

 

14:00-15:30        Poster session

 

 

Session 3 - Serpins in health and disease II - 15:30-17:30

 

Maurizio Molinari (IRB USI, Switzerland)
Understanding the molecular mechanisms of lysosomal clearance of ATZ polymers

 

Marie-Christine Bouton/Véronique Arocas (INSERM Paris, France)
Protective role of the SerpinE2 PN-1 in renal disease

 

Malin Fromme (University Hospital RWTH Aachen, Germany)

 

Ilaria Ferrarotti (University of Pavia, Italy)

 

Speakers to be selected from abstracts

 

 

18:00                Meeting dinner

 

 

Friday 30th May 2025

 

Session 4 - Structural and molecular mechanisms - 9:00-13:00

 

Lisa Cabrita (University College London, UK)

 

Giuseppe Legname (SISSA, Italy)
The role of SERPINA3 in the pathology of prion disorders

 

Speakers to be selected from abstracts

 

Coffee break

 

Aiwu Zhou (Shanghai Jiaotong University, China)
How the specificity of kallistatin is modulated by heparin

 

Konstantinos Thalassinos (University College London, UK)
Top-down ion mobility mass spectrometry reveals a disease associated conformational ensemble of alpha-1-antitrypsin

 

Nunzia Pastore (TIGEM, Italy)

 

Ilaria Fregno (IRB USI, Switzerland)
ERAD vs ERLAD: Degradation of misfolded α1AT variants from the ER

                

Speakers to be selected from abstracts

 

 

13:00-14:00        Lunch (provided)

 

 

Session 5 - Applications, tools and new perspectives - 14:00-16:30

 

Federica Michielin (UCL - GOS Institute of Child Health London, UK)

 

Adriana Ordoñez (University of Cambridge, UK)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response

 

Speakers to be selected from abstracts

 

 

Concluding remarks

 

 

 

 

 

Current as of February 26th, 2025