EUROSERPIN2025 Programme (provisional)
Monastero di San Faustino Maggiore, Brescia, 28-30 May 2025
Wednesday 28th May 2025
13:00-14:00 Registration
14:00-14:15 Welcome address
Session 1 - Serpins in health and disease I - 14:15-17:40
Robin Carrell (University of Cambridge, UK)
Stefan Marciniak (University of Cambridge, UK)
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
Rick Sifers (Baylor College of Medicine, USA)
Utilization of SERPINA1 and patient genetics to elucidate the regulation of the Hepatocyte Proliferation Response
Sonia Caccia (University of Milan, Italy)
Impact of C1-inhibitor binding to endothelial cells on the regulation of vascular permeability
Coffee break
Sabina Janciauskiene (Hannover Medical School, Germany)
α-1-Antitrypsin C-terminal peptides: biomarkers and therapeutic targets in disease
Javier Corral (University of Murcia-IMIB, Spain)
Antithrombin deficiency update. What's up doc?
John Heiker (Helmholtz Munich, Germany)
DNA binding of vaspin (SERPINA12)
Speakers to be selected from abstracts
Thursday 29th May 2025
Session 2 – Therapies, diagnostics and disease models - 9:00-13:00
David Lomas (University College London, UK)
Towards a small molecule therapy for alpha-1 antitrypsin deficiency
Patrizia Pontisso (University of Padova, Italy)
Title TBD
Speakers to be selected from abstracts
Coffee break
Alexandra Lucas (Arizona State University, USA)
Title TBD
Tamir Rashid (Imperial College London, UK)
Induced pluripotent stem cell therapies
Beatriz Martinez Delgado (Carlos III Health Institute, Spain)
Metabolic alterations in AATD cellular models and patient-derived liver organoids
Speakers to be selected from abstracts
13:00-14:00 Lunch (provided)
14:00-15:30 Poster session
Session 3 - Serpins in health and disease II - 15:30-17:30
Maurizio Molinari (IRB USI, Switzerland)
Understanding the molecular mechanisms of lysosomal clearance of ATZ polymers
Marie-Christine Bouton (INSERM Paris, France)
Specific platelet targeting of serpinE2 for haemophilia treatment
Malin Fromme (University Hospital RWTH Aachen, Germany)
Title TBD
Bibek Gooptu (University of Leicester, UK)
Title TBD
Speakers to be selected from abstracts
18:00 Meeting dinner
Friday 30th May 2025
Session 4 - Structural and molecular mechanisms - 9:00-13:00
Lisa Cabrita (University College London, UK)
Title TBD
Giuseppe Legname (SISSA, Italy)
The role of SERPINA3 in the pathology of prion disorders
Speakers to be selected from abstracts
Coffee break
Aiwu Zhou (Shanghai Jiaotong University, China)
How the specificity of kallistatin is modulated by heparin
Konstantinos Thalassinos (University College London, UK)
Top-down ion mobility mass spectrometry reveals a disease associated conformational ensemble of alpha-1-antitrypsin
Nunzia Pastore (TIGEM, Italy)
Title TBD
Adriana Ordoñez (HiTech, Catholic University of San Antonio of Murcia)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response
Speakers to be selected from abstracts
13:00-14:00 Lunch (provided)
Session 5 - Applications, tools and new perspectives - 14:00-16:30
Federica Michielin (UCL - GOS Institute of Child Health London, UK)
Modelling Alpha-1 antitrypsin deficiency with patient-derived hepatic organoids.
Ilaria Ferrarotti (University of Pavia, Italy)
Title TBD
Ilaria Fregno (IRB USI, Switzerland)
ERAD vs ERLAD: Degradation of misfolded α1AT variants from the ER
Speakers to be selected from abstracts
Concluding remarks
Current as of April 21st, 2025