EUROSERPIN2025 Programme (provisional)

 

Monastero di San Faustino Maggiore, Brescia, 28-30 May 2025

 

 

Wednesday 28th May 2025

 

 


13:00-14:00        Registration

 


14:00-14:15        Welcome address

 

 

Session 1 - Serpins in health and disease I - 14:15-18:00

 

 


Robin Carrell
(University of Cambridge, UK)



Stefan Marciniak (University of Cambridge, UK)
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency

 

 

Rick Sifers (Baylor College of Medicine, USA)
Utilization of SERPINA1 and patient genetics to elucidate the regulation of the Hepatocyte Proliferation Response

 

 

Sonia Caccia (University of Milan, Italy)
Impact of C1-inhibitor binding to endothelial cells on the regulation of vascular permeability

 

 

Giovanna Galliciotti (University Medical Center Hamburg-Eppendorf, Germany)
Neuroserpin’s role in hippocampal development and plasticity: beyond inhibition

 

 

Coffee break

 

 

Bibek Gooptu (University of Leicester, UK)
Title TBD

 

 

Javier Corral (University of Murcia-IMIB, Spain)
Antithrombin deficiency update. What's up Doc?

 

 

S. Patricia Becerra (National Eye Institute, National Institutes of Health, USA)
PEDF, a non-inhibitory serpin, in retinal degeneration, aging, and peptide-based therapy


Anna Quintiliani (Sapienza University of Rome, Italy)
Analysis of novel variants of neuroserpin that cause neurodegeneration FENIB

 

 

Thursday 29th May 2025

 

 

 

Session 2 – Therapies, diagnostics and disease models - 9:00-13:00

 

 


David Lomas
 (University College London, UK)
Towards a small molecule therapy for alpha-1 antitrypsin deficiency

 

 

Alexandra Lucas (Arizona State University, USA) 

Title TBD



Elena Miranda (Sapienza University of Rome, Italy)
Antioxidant deprivation exacerbates neuroserpin polymer toxicity in a neuronal model of FENIB


Sihong Song (University of Florida, USA)
Application of alpha-1 antitrypsin (AAT) in lupus mouse models


Leonie De Wilde (University of Antwerp, Belgium)
SERPINA3 as a promising biomarker and target in doxorubicin-induced cardiovascular toxicity


Stefania Ottaviani (University of Pavia, Italy)
Alpha1-antitrypsin M-like variants: the importance to detect the Mwhitstable intronic mutation

 

 

Coffee break

 

 

Tamir Rashid (Imperial College London, UK)
Induced pluripotent stem cell therapies

 

 

Beatriz Martinez Delgado (Carlos III Health Institute, Spain)
Metabolic alterations in AATD cellular models and patient-derived liver organoids


Patrizia Pontisso (University of Padova, Italy)
Inhibition of SerpinB3/PAR2 axis as potential innovative treatment for glioblastoma


Mireille Dumoulin (University of Liège, Belgium)
A single-domain antibody fragment (VHH) inhibiting neutrophil elastase for the treatment of inflammatory lung diseases


Riccardo Ronzoni
(University College London, UK)
Susceptibility of alpha1 antitrypsin deficiency variants to polymer blocking therapy

 

 

 

13:00-14:00        Lunch (provided)

 

 

 

14:00-15:30        Poster session

 

 

 

 

Session 3 - Serpins in health and disease II - 15:30-18:00

 

 


Maurizio Molinari
 (IRB USI, Switzerland)
Understanding the molecular mechanisms of lysosomal clearance of ATZ polymers

 

 

Marie-Christine Bouton (INSERM Paris, France)
Specific platelet targeting of serpinE2 for haemophilia treatment

 

 

Malin Fromme (University Hospital RWTH Aachen, Germany)

Title TBD

 

 

Sabina Janciauskiene (Hannover Medical School, Germany)
α-1-Antitrypsin C-terminal peptides: biomarkers and therapeutic targets in disease



Claudia D'Agostino (TIGEM, Italy)
Uncovering the role of lysosomes in the pathology of the AATD-related liver disease


Véronique Arocas (INSERM Paris, France)
Protective role of the SerpinE2 PN-1 in renal disease


Anna Fra (University of Brescia, Italy)
A novel assay for the quantification of alpha-1-antitrypsin inhibitory capacity in human plasma

 

 

 

18:30                Meeting dinner

 

 

 

 

Friday 30th May 2025

 

 

 

Session 4 - Structural and molecular mechanisms - 9:00-13:00

 

 


Lisa Cabrita
 (University College London, UK)

Title TBD

 

Giuseppe Legname (SISSA, Italy)
The role of SERPINA3 in the pathology of prion disorders


Adriana Ordoñez (HiTech, Catholic University San Antonio of Murcia)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response


John Heiker
(Helmholtz Munich, Germany)
DNA binding of vaspin (SERPINA12)



Lily Wu (University of Cambridge, UK)
Molecular mechanisms conferred by somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency

 

Coffee break

 

 

Aiwu Zhou (Shanghai Jiaotong University, China)
How the specificity of kallistatin is modulated by heparin

 

 

Konstantinos Thalassinos (University College London, UK)
Top-down ion mobility mass spectrometry reveals a disease associated conformational ensemble of alpha-1-antitrypsin

 

 

Nunzia Pastore (TIGEM, Italy)

Polymeric ATZ disrupts intestinal homeostasis and enhances susceptibility to colitis in mice

 

 

Adriana Ordoñez (HiTech, Catholic University of San Antonio of Murcia, Spain)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response


Ilaria Fregno (IRB USI, Switzerland)
ERAD vs ERLAD: Degradation of misfolded α1AT variants from the ER


Sarah Lowen (University College London)
High-resolution characterisation of alpha-1-antitrypsin by NMR spectroscopy

 

 

 

13:00-14:00        Lunch (provided)

 

 

 

 

Session 5 - New perspectives - 14:00-16:30

 

 


Ilaria Ferrarotti
(University of Pavia, Italy)
New methods for the correct diagnosis of AATD


Federica Michielin
(UCL - GOS Institute of Child Health London, UK)

Modelling alpha-1 antitrypsin deficiency with patient-derived hepatic organoids

 

 

James Irving (University College London, UK)
The serpin fold at the extreme

 

 

Santina Quarta (University of Padova, Italy)
SERPINB3/protease activated receptor-2 axis is essential for SARS COV-2 infection


Tadhg Kilbane
(University of Galway, Ireland)
Serpins of the human worm parasites Schistisoma mansoni and Fasciola hepatica


Nina Heyer-Chauhan
(University College London, UK)
Resolution of pathogenic circulating Z alpha-1-antitrypsin polymers following orthotopic liver transplantation


 

Concluding remarks

 

 

 

 

 

Current as of May 9th, 2025