EUROSERPIN2025 Programme
Monastero di San Faustino Maggiore, Brescia, 28-30 May 2025
Wednesday 28th May 2025
13:00-14:00 Registration
14:00-14:15 Welcome address: Anna Fra and Riccardo Ronzoni
Session 1 - Serpins in health and disease I - 14:15-18:00
Chairs: Elena Miranda and Javier Corral
Robin Carrell (University of Cambridge, UK)
What serpins told us about maternal mortality
Stefan Marciniak (University of Cambridge, UK)
Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
Rick Sifers (Baylor College of Medicine, USA)
Utilization of SERPINA1 and patient genetics to elucidate the regulation of the Hepatocyte Proliferation Response
Sonia Caccia (University of Milan, Italy)
Impact of C1-inhibitor binding to endothelial cells on the regulation of vascular permeability
Giovanna Galliciotti (University Medical Center Hamburg-Eppendorf, Germany)
Neuroserpin’s role in hippocampal development and plasticity: beyond inhibition
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Chairs: Anna Fra and Stefan Marciniak
Bibek Gooptu (University of Leicester, UK)
Alpha1-antitrypsin misfolding and ER-associated degradation in disease
Javier Corral (University of Murcia-IMIB, Spain)
Antithrombin deficiency update. What's up Doc?
S. Patricia Becerra (National Eye Institute, National Institutes of Health, USA)
PEDF, a non-inhibitory serpin, in retinal degeneration, aging, and peptide-based therapy
Anna Quintiliani (Sapienza University of Rome, Italy)
Analysis of novel variants of neuroserpin that cause neurodegeneration FENIB
M. Eugenia de la Morena-Barrio (University of Murcia-IMIB, Spain)
Hemostatic impact of α1-antitrypsin Pittsburgh, a pan hemostatic serpin
Thursday 29th May 2025
Session 2 – Therapies, diagnostics and disease models - 9:00-13:00
Chairs: Riccardo Ronzoni and Adriana Ordoñez
David Lomas (University College London, UK)
Towards a small molecule therapy for alpha-1 antitrypsin deficiency
Alexandra Lucas (Arizona State University, USA)
Virus-derived serpin interaction with mammalian serpins - serpinosome
Elena Miranda (Sapienza University of Rome, Italy)
Antioxidant deprivation exacerbates neuroserpin polymer toxicity in a neuronal model of FENIB
Sihong Song (University of Florida, USA)
Application of alpha-1 antitrypsin (AAT) in lupus mouse models
Leonie De Wilde (University of Antwerp, Belgium)
SERPINA3 as a promising biomarker and target in doxorubicin-induced cardiovascular toxicity
Stefania Ottaviani (University of Pavia, Italy)
Alpha1-antitrypsin M-like variants: the importance to detect the Mwhitstable intronic mutation
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Chairs: Giovanna Galliciotti and Rick Sifers
Tamir Rashid (Imperial College London, UK)
Induced pluripotent stem cell therapies
Beatriz Martinez Delgado (Carlos III Health Institute, Spain)
Metabolic alterations in AATD cellular models and patient-derived liver organoids
Patrizia Pontisso (University of Padova, Italy)
Inhibition of SerpinB3/PAR2 axis as potential innovative treatment for glioblastoma
Mireille Dumoulin (University of Liège, Belgium)
A single-domain antibody fragment (VHH) inhibiting neutrophil elastase for the treatment of inflammatory lung diseases
Riccardo Ronzoni (University College London, UK)
Susceptibility of alpha1 antitrypsin deficiency variants to polymer blocking therapy
13:00-14:00 Lunch (provided)
14:00-15:30 Poster session
Session 3 - Serpins in health and disease II - 15:30-18:00
Chairs: Joe Chambers and S. Patricia Becerra
Maurizio Molinari (IRB USI, Switzerland)
Understanding the molecular mechanisms of lysosomal clearance of ATZ polymers
Marie-Christine Bouton (INSERM Paris, France)
Specific platelet targeting of serpinE2 for haemophilia treatment
Malin Fromme (University Hospital RWTH Aachen, Germany)
AATD-associated liver disease – clinical and translational perspective
Sabina Janciauskiene (Hannover Medical School, Germany)
α-1-Antitrypsin C-terminal peptides: biomarkers and therapeutic targets in disease
Claudia D'Agostino (TIGEM, Italy)
Uncovering the role of lysosomes in the pathology of the AATD-related liver disease
Véronique Arocas (INSERM Paris, France)
Protective role of the SerpinE2 PN-1 in renal disease
Mattia Bignotti (University of Brescia, Italy)
A novel assay for the quantification of alpha-1-antitrypsin inhibitory capacity in human plasma
18:30 Meeting dinner
Friday 30th May 2025
Session 4 - Structural and molecular mechanisms - 9:00-13:00
Chairs: James Irving and Nunzia Pastore
Lisa Cabrita (University College London, UK)
Exploring antitrypsin misfolding and polymerisation during biosynthesis on the ribosome
Giuseppe Legname (SISSA, Italy)
The role of SERPINA3 in the pathology of prion disorders
Adriana Ordoñez (HiTech, Catholic University San Antonio of Murcia, Spain)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response
John Heiker (Helmholtz Munich, Germany)
DNA binding of vaspin (SERPINA12)
Lily Wu (University of Cambridge, UK)
Molecular mechanisms conferred by somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency
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Chairs: Mauro Manno and Lisa Cabrita
Aiwu Zhou (Shanghai Jiaotong University, China)
How the specificity of kallistatin is modulated by heparin
Konstantinos Thalassinos (University College London, UK)
Top-down ion mobility mass spectrometry reveals a disease associated conformational ensemble of alpha-1-antitrypsin
Nunzia Pastore (TIGEM, Italy)
Polymeric ATZ disrupts intestinal homeostasis and enhances susceptibility to colitis in mice
Adriana Ordoñez (HiTech, Catholic University of San Antonio of Murcia, Spain)
Uncovering adaptive genes that mitigate serpin polymerization toxicity and their link to the unfolded protein response
Ilaria Fregno (IRB USI, Switzerland)
ERAD vs ERLAD: Degradation of misfolded α1AT variants from the ER
Sarah Lowen (University College London, UK)
High-resolution characterisation of alpha-1-antitrypsin by NMR spectroscopy
13:00-14:00 Lunch (provided)
Session 5 - New perspectives - 14:00-15:55
Chairs: Marie-Christine Bouton and Konstantinos Thalassinos
Ilaria Ferrarotti (University of Pavia, Italy)
New methods for the correct diagnosis of AATD
Federica Michielin (UCL - GOS Institute of Child Health London, UK)
Modelling alpha-1 antitrypsin deficiency with patient-derived hepatic organoids
Santina Quarta (University of Padova, Italy)
SERPINB3/protease activated receptor-2 axis is essential for SARS COV-2 infection
Tadhg Kilbane (University of Galway, Ireland)
Serpins of the human worm parasites Schistisoma mansoni and Fasciola hepatica
Nina Heyer-Chauhan (University College London, UK)
Resolution of pathogenic circulating Z alpha-1-antitrypsin polymers following orthotopic liver transplantation
James Irving (University College London, UK)
Optimisation at the serpin-protease interface
Concluding remarks: Giovanna Galliciotti and Joe Chambers
Current as of May 28th, 2025